Abstract

Four cases of urolithiasis with the primary hyperparathyroidism due to adenoma of the parathyroid gland were experienced in the period of 22 months, September 1958 through June 1960. The present cases are considered to be the first to the fourth clinically proved cases of urolithiasis due to primary hyperparathyroidism in Japan.These four cases correspond to 2.5% of urolithiasis and 3.2% lithiasis of the upper urinary tract treated during the same period. Primary hyperparathyroidism must always be suspected whenever multiple or recurrent calculi are found in the urinary tract.Several kinds of newer laboratory test, such as urine concentration test, estimation of % TRP, phosphate deprivation test, calcium tolerance test and estimation of parathyroid index, were applied to these cases. From the good results of these tests, it is considered that these tests should be performed as important methods for diagnosis of primary hyperparathyroidism.Several aspects of this disease are discussed.

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