Abstract
The main alkaloids of opium, morphine, codeine, papaverine, narcotine, and dihydrocodeine, form a salt with various organic and inorganic acids. The water-soluble salts of these alkaloids have a strong bitter taste and are disliked for oral use. The artificial sweetening, saccharin, is a kind of acid and salt-formation of these alkaloids with saccharin was attained by heating a mixture of the alkaloid and saccharin in organic solvent. The salt thereby formed has a sweet taste, the sweetness of saccharin shielding the bitterness of the base, and is a water-soluble salt of uniform composition.
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