Abstract
<p indent=0mm>Cardiovascular disease is the leading cause of death worldwide, and the coronary artery disease (CAD) is the main factor leading the cardiovascular disease. However, there is still leaking efficient clinical treatment to CAD until now. An in-depth understanding of the formation of coronary vessels during development and regeneration after heart injury will provide more ideas for developing treatment strategies of coronary diseases. Recently, with the development of the genetic lineage tracing technology <italic>in vivo</italic>, scientists have gained some new insights into the cellular origins and molecular mechanisms of coronary blood vessel formation during development and regeneration. These mechanisms provide new possibility for improving heart repair by targeting new vessels formation. Here, we highlight these recent finding about the development and regeneration of coronary vessels and discuss the possible application value in the treatment of ischemic heart disease.
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