Abstract
Serum lipids were studied in 17 patients with multiple myeloma. Total cholesterol, low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol levels (mean±SD) were significantly reduced in 6 patients with plasma cells over 30 per cent in bone marrow compared to 28 normal subjects (103±34mg/dl versus 172±24mg/dl, 46±19mg/dl versus 94±17mg/dl and 39±21mg/dl versus 53±11mg/dl respectively). Otherwise, hypocholesterolemia were not observed in 11 patients with small amount of plasma cells (less than 29%). There was a negative correlation between serum cholesterol and M-protein in multiple myeloma and also a rise towards a normal cholesterol level as a result of the effective treatment.LDL catabolism is mainly mediated through the LDL receptor pathway in the parenchymal cells. The effect of M-protein on LDL receptor was studied in cultured human skin fibroblasts. No increase of LDL uptake and degradation was observed with M-protein.Low serum cholesterol levels seems to be mediated by the high serum M-protein level or the great amount of plasma cells in bone marrow. Levels of serum total and lipoprotein cholesterol provide valuable informations in assessment of the disease activity.
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