Abstract

Ethanolamine oleate injection containing 30% iopamiron 300 (30% IP 300-E0) has been previously prepared for endoscopic sclerotherapy of esophageal varices on X-ray TV monitor. However, the ability of fluoroscopic visualization of this sclerosing agent was slightly insufficient in clinical use.We prepared ethanolamine oleate injection containing 30% iopamiron 370 (30% IP 370-E0), and measured the physical characteristics such as viscosity and osmotic pressure of this agent.The ability of visualization was observed in patients with esophageal varix by X-ray.The viscosity, which was inversely related to the injectability into varices, of 30% IP 370-E0 was relatively low and its osmotic nressure was almost the same as that of normal saline.30% IP 370-E0 was easily injected into varices.Better fluoroscopic visualization was obtained by intravariceal injection with 30% IP 370-E0 than with 30% IP 300-E0.These results suggest that 30% 1P370-E0 is more useful agent for endoscopic sclerotherapy of esophageal varices.

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