植物雌激素防治围绝经期综合征

Abstract

植物雌激素是天然植物化合物，结构或功能与雌二醇相同。有雌激素或抗雌激素双向调节作用，对激素相关性疾病具有广泛防治作用。已有研究显示植物雌激素对围绝经期血管舒缩症状及绝经后的风险有益，安全而无增加阴道出血、子宫内膜增生、子宫内膜癌及乳房癌。植物雌激素是有希望的围绝经期综合征替代药物。 Phytoestrogens are natural plant compounds that are structurally or functionally similar to estradiol, which have both estrogenic and anti-estrogenic activity, displaying a two-way regulation ability and extensive preventive and therapeutic effects on hormone-related diseases. Studies demonstrate the benefit of phytoestrogens in addressing the perimenopausal vasomotor symptoms and postmenopausal health risks. Phytoestrogens have a safe side-effect profile with no increased rates of vaginal bleeding, endometrial hyperplasia, endometrial cancer, and breast cancer. They offer a promising alternative to conventional hormone replacement therapy for perimenopausal syndrome.