アミノ配糖体抗生物質で治療を受けた入院患者における体内動態の個体内変動とＣ反応性蛋白質との相関性

Abstract

To evaluate the correlation between the intra-individual variations in the pharmacokinetics of aminoglycoside (arbekacin and amikacin) and C-reactive protein (CRP), the serum concentrations of aminoglycoside and the CRP levels were monitored in 10 inpatients receiving arbekacin or amikacin therapy. The pharmacokinetic parameters of aminoglycoside were estimated using a one-compartment model.A significant difference was observed between the distribution volume at higher CRP levels and lower levels in inpatients receiving aminoglycoside (Vd, 0.442±0.134 vs 0.368±0.164 L/kg, P< 0.05), However, no significant relationship existed between the CRP levels and Vd of aminoglycoside, There was a significant difference in the half-life (t1/2) of seruim aminoglycoside between higher CRP levels and lower levels in inpatients receiving aminoglycoside (3.90±1.97 vs 4.46±2.02 hours, P< 0. 01).In the future, further examinations of serum aminoglycoside concentration monitoring are called for to check the intra-individual variations in the pharmacokinetics for aminoglycoside, when the CRP levels change in inpatients receiving aminoglycoside therapy.