Abstract
Adrenal regeneration hypertension was performed on Wistar rats, WKY and SHR by Skelton's method. For the first time, we observed glomerular foam cell in the kidneys of those experimental rats. Glomerular foam cells were seen in the rats that were markedly hypertensive and hypercholesterolemic state, and in those that showed a high secretion of protein in the urine. We suggested that those experimental rats exhibited the state of nephrotic syndrome.Glomerular foam cells were noticed in approximately one-third of the rats. Moreover, we found glomerular foam cells in all of the Wistar rats and WKY fed a high cholesterol diet, that is, a 5 percent cholesterol and 2 percent cholic acid-including diet. An electron microscopic study of the glomerular foam cells revealed that the cell origin was probably circulating monocyte and mesangial cell. Glomerular foam cells were located in the mesangial matrix or subendothelium of the glomerular capillary.
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