Abstract
In this report, I have made clear that the susceptibility of mice to the mouse encephalomyelitis virus was markedly increased when mice were treated with effective dose of Cortisone. 1) Multiplication of the virus in the brain was promoted. 2) Appearance of dermal inflammatory reaction by turpentine oil was delayed but an obvious effect on the cellular reaction in the brain when the virus made a remarkable multiplication could not be observed and it was known, in general, that appearance of the cellular reaction was slow compared with the rate of multiplication of the virus. 3) Phagocytic function of subcutaneous tissue cell decreased. 4) Antibody formation decreased but the mechanism of promoting the multiplication of virus proceeded this, and gave no effect on the existing antibodies. 5) Anatomically the atrophy of spleen and whole lymph nodes was remarkable. 6) No direct change on blood sugar level was observed regardless of infection with the virus. No immediate remarkable effect on serum protein was observed, but the rise of globulin following the infection could not be confirmed among the mice treated with Cortisone.Therefore, when the way of thinking about the susceptibility is divided into the following two, the receptibity and the vulnerability, effect of Cortisone which increases the susceptibility is to increase the receptibity which allows the multiplication of pathogenic microorganism and the vulnerability which rises the symptome, on the contrary, seems to be decreased.* The hypofunction of R. E. system following the atrophy of spleen is the subject to be thoroughly searched in explaining the function of Cortisone. It seems that there are still doubtful points to be explained in the relation of the susceptibility to virus and the meaning mentioned above. (These points will be reported later.)
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