附子の薬理作用

Abstract

The pharmacological properties of raw Aconitum roots from Niigata (1), Hokkaido (2) and China (3) and their processed preparations (4, 5 and 6, respectively) were examined in comparison with their constituents, aconitine (AC) and benzoylaconine (BA) (doses expressed in per kg p.o. in vivo, unless otherwise stated, and per ml in vitro). On blood pressure in rats, 1, 3 (0.1 g i.v.) and AC (50μg i.v.) exhibited a weak temporary hypotensive action, while 2 (0.1 g i.v.) elicited a diphasic reaction, a remarkable hypertension followed by hypotension. 4-6 (0.1 g i.v.) mediated marked temporary hypertensive action. In the isolated right atria of guinea pigs, 1-3 (10-6-10-5g) showed positive inotropic and chronotropic action. Further, 1-3 (10-4g) and AC (10-7g) exhibited these actions followed by negative inotropic action and disorder of the heart rate. In the isolated ileum of guinea pigs, 1-3 (10-4g) and AC (10-6g) caused weak contraction which was antagonized by atropine. In the isolated vas deferens of guinea pigs, 1-6 (10-4g), AC and BA (10-5g) produced no contraction, and had no effect on contraction induced by norepinephrine or tyramine. In the isolated hypogastric nerve-vas deferens of guinea pigs, the isolated mesenteric nerve-jejunum of rabbits and the isolated phrenic nerve-diaphragm of rats, 1-3 (10-4g) and AC (10-6g) inhibited responses induced by electrical stimulation of the corresponding nerves. In mice, 1-2 (0.1-1.0g) showed analgesic activity in the tail pressure method and 1-3 in the acetic acid-induced writhing method. In mice, 1-3 (0.1-1.0g) potentiated hexobarbital anesthesia. In mice, 1-3 (0.1-1.0g) and AC (1 mg) reduced revolution of the wheel cage. In mice, 3 (1.0 g) and AC (1 mg) showed hypothermic action by 1.5-2°. In mice, 1-3 (0.1-1.0g) inhibited the stress-induced ulcer production.