Abstract
A malignant myoepithelioma arising in the soft palate of a 63-year-old woman is reported. On light microscopy, the tumor was found to be composed of myoepithelial cells with clear cytoplasm and appeared to be malignant. These cells were partially encapsulated, but focally invaded the capsule and adjacent salivary gland tissue. Immunohistochemical studies showed positive staining for S-100 protein and vimentin and negative staining for cytokeratin, GFAP, amylase, and α-smooth muscle actin in the tumor cells. A review of this case and existing reports indicates that malignant myoepitheliomas exhibit a wide range of histological characteristics.
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