Abstract
Dialdehyde cellulose (DAC), modified by chitosan coating (chitosanDAC) and iron chitosan complex, developed as oral sorbents for urea and phosphate removal, were reported in previous papers. In this paper, chitosanDAC, iron chitosancomplex and chitosan were tested for removal of uric acid, quinolinic acid, trans-aconitic acid and 2, 5-furan dicarboxylic acid, which are main acidic substances existed in uremic toxins. In-vitro experiments have shown that chitosanDAC and chitosan remove these acidic substances by adsorption in high rate and capacity. Chronic renal failure rats were fed on the standard diet with or without chitosanDAC (5 % content)for about two months. Rats received chitosanDAC showed 8 % decrease of blood uric acid compared with rats received the normal diet.
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