動脈内圧上昇による動脈壁傷害とその修復に関する実験病理学的研究

Abstract

It is well known that hypertension produces arterial lesion, which advances until it brings about grave result for the living body. It is, however, scarcely known what behavior the arterial wall will take exclusively as the result of elevation of intravascular pressure.A method of local control of intravascular pressure, which was devised by the authors, was simultaneously applied to the rabbit's common carotid artery and thyroid artery to observe, in the course of time, mural injury produced by elevated intravascular pressure. Furthermore, the circumferential tension due to the local control on intravascular pressure was computed by the Azuma-Oka's formula (T=P1γ1'-P2γ2') in order to pursue the relation between change in the circumferential tension and arterial lesion. No injury was given to the artery when the intra-vascular pressure produced negative circumferential tension. The intravascular pressure which gave T=0 was about 150mmHg for the common carotid artery, and somewhat higher for the thyroid artery.Medial hypertrophy observed in hypertension is considered to be an accomodation favorable to be living body, and the intimal thickening may be a compensatory phenomenon in case of failure of the medial hypertrophy. Since the reactive hypertrophic intima can not possess the perfectly same morphology and function with the genuine media, the fomer may not prevent the lesion from advancing to arteriosclerosis.