Abstract
The evidence of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) is introduced. SCIT and SLIT is an allergen immunotherapy used internationally now. In Japan, SCIT is still the only immunotherapy. There are no evidence-based protocols for SCIT but the effect is reliable with high level evidences including the meta-analysis. Although the effect of SCIT is large, the social problems around the medical system in Japan prevent SCIT from general usage. SLIT is another immunotherapy that is internationally evaluated as an effective therapy. SLIT is handier to perform and is gathering attention. Some double-dummy tests reported that SLIT was as effective as SCIT, but the effectiveness of SLIT compared to that of SCIT is still controversial. Many doctors and patients are longing for SLIT to be available in Japan. We are aiming to put SLIT to pollinosis caused by Japanese cedar pollen in practical use at 2014.
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