Abstract
Serum levels of the nadolol stereoisomers, racemate A and B, in man were determined by high-performance liquid chromatography using a fluorescence detector following single oral administration at a dose of 60mg. The mean serum levels of racemate A and B were maximal 3.6h after dosings of nadonol racemate A and B with levels of 23.6 and 22.5ng/ml, respectively, followed by a biphasic decrease with apparent terminal elimination half-lives of 19.7 and 16.5h, respectively. Paired statistically significiant differences were found for serum levels, elimination of half-lives and the area under the curve following the nadolol dosing of racemate A and B. An average of 28.4% and 23.6% of racemate A and B were respectively bound to serum protein, suggesting that serum levels and elimination of the half-lives of racemate A and B were different. Also, significant differences were found for serum levels of racemate A and B after constant administration of 30mg of nadolol per day in 17 patients.
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