Abstract
Single-phase powders of γ-Ce2Mo3O13, Ce8Mo12O49, and Ce2Mo4O15 were prepared using the solid-phase method. Then, the antiviral activity of these powders against the non-enveloped virus bacteriophage Qβ and the enveloped virus bacteriophage Φ6 were evaluated. Moreover, H2O2 assay and catalase inactivation test were performed. Regarding the antiviral activity of the prepared samples, the activity against bacteriophage Φ6 was higher than the activity against bacteriophage Qβ. The antiviral activity order for bacteriophage Φ6 was correlated with the amount of H2O2 generated and the catalase inactivation rate. It depended also on the eluted Ce/Mo ratio. These results imply that the antiviral activity on bacteriophage Qβ is influenced by neutralization of the negative charge of capsid by rare earth ions and by adsorption of heteropolyacids to specific sites of the virus. Results suggest that the oxidation reaction of Ce (IV) or of the H2O2, and the adsorption of heteropolyacids formed by Ce and molybdate ions affect the antiviral activity against bacteriophage Φ6. Among the compounds examined this time, γ-Ce2Mo3O13 exhibited the highest antiviral activity against bacteriophage Φ6.
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