Abstract
The number of patients with syphilis in Japan had decreased gradually after reaching a peak in 1960, but an increasing trend has been evident since 1985. Since this increase has been triggered by a rise in early syphilis, a future epidemic is expected.The patient was a 22-year-old male suffering from a mucosal lesion of the lower lip and submandibular, cervical lymph node swelling. The painless mucosal erosion had a slightly indurated margin. Serological examination revealed elevated values for the TPHA-test (titer of 1: 1, 280) and RPR-test (1: 64). By using the Warthin-Starry method and TPHA-IgM, however, Treponema pallidum could not be stained in the biopsy specimen taken from the lower lip lesion.The patient was treated orally with ABPC 1.5g/day for four weeks, which was sufficient to eliminate the syphilitic lesion. The blood serological data entered the normal range 9 weeks after initiating the administration of antibiotics.
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