中等度悪性非ポジキンリンパ腫の臨床統計

Abstract

We made a retrospective clinical study of 43 cases of intermediate-grade non-Hodgkin's lymphomas, initially treated at our university between January 1975 and July 1992.The median age of the patients was 61 years. In the majority of the patients (55.1%), Waldeyer's ring was the origin, while in 25.6%, the origin was extranodal other than Waldeyer's ring and in 23.3%, the origin was nodal system. According to the stage distribution for Ann Arbor classification,16 cases were stage I,16 were stage III,8 were stage III and 3 were stage IV.The five-year survival rate was 82.2% for stage I + II,51.5% for stage III + IV and 73.9% overall. As to therapy, radiation therapy alone was performed in 3, chemotherapy alone in 6 and chemotherapy with radiation therapy in 33 cases. The rates of complete remission were 100%,50.0% and 78.8% respectively, and the five-year survival rates were 50.0%,83.3% and 76.7% respectively.After achievement of complete remission, intensification therapy was performed in 20cases and not performed in 13 cases. Five-year survival rate were 100% and 62.3% respectively.There result showed that the effectiveness of front-line therapy and the performance of intensification therapy were the most significant factors for improving 5-year survival and decreasing the rate of relapse.