Abstract
Various sclerosants for esophageal varices (polidocanol; PO, ethanolamine oleate; EO, human thrombin; TH, absolute ethanol; ET, sodium tetradecyl sulfate; STS) were injected into mongrel dogs to clarify the effects on blood coagulation, fibrinolysis and histological changes. Hemolysis and thrombocytopenia were observed in all dogs treated with sclerosants. Prolongation of prothrombin time and activated partial thromboplastin time were observed in dogs of EO, TH and STS groups. Plasma fibrinogen decreased significantly in dogs with TH. No remarkable changes of plasminogen and antithrombin-III were observed in any dogs. α2-plasmin inhibitor decreased to 50-70% in ET, TH and STS groups. Degree of tissue damage caused by sclerosant was most remarkable in ET group. It caused necrosis around the vessel. STS and EO groups, however, showed mild damage of the vessels than ET group. They caused thrombi for more than a week, and after a month, organization of the vessel space. So at the sclerotherapy for esophageal varices, we should use sclerosants considering these effects.
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