Abstract
The cavitation of a liposome microbubble dynamics in drug release was studied.The main objective of this work was to investigate the role by the mechanical index(MI) in the 300 kHz and 1MHz ultrasound.Several simulations indicated that bubble radius changes quickly from maximal value to zero by the driving frequency.Drug release was more efficient at 300 kHz compared to 1 MHz when MI was greater than 0.4.When the MI was less than 0.4,drug release was more efficient at 1 MHz compared to 300 kHz.The results demonstrate that ultrasound has a potential in enhancing drug release from liposome.
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