肺結核空洞注入療法に関する研究

Abstract

The author studied in the course of treatment the changes in the cellular composition and pH in the sputum of 7 patients given IHMS intra-cavity injection and of 3 patients given SM injection, and also by inducing the experimental pulmonary cavities in rabbits according to Yamamura's method, the author successfully gave the intra-cavity injection of SM in one case and INAH in two cases, and obtained the following results in respective cases:1. By the intra-cavity injection of drugs neutrophils increase and lymphccytes decrease in the sputum, and these either increase or decrease rapidly after about 5-10 rounds of injections.2. No striking changes can be recognized in lung cells and bronchial epithelial cells.3. PH of the sputum rises slightly by the intra-cavity injection, turning to weak alkaline.4. Of the seven rabbits with experimental pulmonary cavity the intra-cavity injection of SM was successful in one and of INAH in two.5. By SM injection the cavity becomes a giant cystic cavity, showing marked growth of granulation and connective tissues; and the vigorous action of the mechanism healing the cavity can be detected, but no tuberculous bacilli.6. In the cases injected with INAH although a slight degree of sterilization, no formation of epithelium can be observed, but showing a marked granulation.The therapeutic effect of INAH injection is inferior to that of SM injection, but no definite conclusion can be given on this point as number of cases handled here are too small.