各種環境要因の血清アポ蛋白に及ぼす影響

Abstract

The relationships among the apolipoproteins (apo), physical variations, nutrition and energy expenditure were studied by using 169 healthy men who had been randomly selected from among 1, 084 male participants in 1989 in Tanushimaru, Kyushu, Japan.The results of the univariate analysis showed that the concentration of apo A-I was positively related to the percentage of calories from alcohol (alcohol (%)), and that the concentration of apo A-II was positively related to obesity and alcohol (%), and negatively related to age and energy expenditure, while, the concentration of apo B was positively related to obesity. Concerning apo C-II, C-III and E, significant relations to energy expenditure and obesity were observed.Multiple linear regression analysis was performed to exclude those factors which had been overestimated by the univariate analysis. Significant correlations between apo A-I and obesity, alcohol (%), smoking and daily cholesterol intake were observed. The concentration of apo A-II was well indicated by age, obesity, energy expenditure, alcohol (%) and smoking. The concentration of apo B was correlated only with obesity, while the apo B/A-I ratio showed a correlation with both obesity and alcohol consumption. Apo C-II, C-III and E were well indicated by daily energy expenditure.Therefore, it is safe to conclude that the metabolism of serum apolipoproteins is influenced by various environmental factors. Further detailed studies on these factors are required to help prevent atherosclerotic diseases through the modification of lifestyles.