Abstract
I investigated the biochemical (Bmax, KD) and functional (contractile force) characteristics of autonomic receptors in the 1-day-old rabbit urinary tract smooth muscle, and compared the data obtained to those already reported in adult rabbits. The rank order of the receptor densities in neonatal rabbits are dome greater than base greater than urethra greater than ureter for alpha 1 (3H-PZ), ureter greater than urethra greater than base greater than dome for alpha 2 (3H-YOH), dome greater than base greater than urethra greater than ureter for beta (3H-DHA) and dome greater than base greater than urethra greater than ureter for muscarinic (3H-QNB). Unlike the findings in the adult rabbit, there is a much larger number of functional muscarinic receptors in the bladder dome and a much smaller number of functional alpha 1-receptors in the urethra of neonatal rabbits. The differences observed in the pattern of distribution of these receptors between neonatal and adult urinary tracts may play a determinant role in the physiological development of the urinary system.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
