创伤后应激障碍的脑功能磁共振成像研究进展

Abstract

创伤后应激障碍(PTSD)是个体直接或间接接触自然灾害、战争、性侵害、严重交通事故、长期监禁与拷问等创伤性事件后所出现的应激相关障碍，对个体的身心健康和社会适应性造成严重损害的一类疾病。近年来，随着医学影像学技术的发展，人们对于创伤后应激障碍的发病机制的研究更加深入，更多的从影像神经学等层面去探讨其发生发展的机理，尤其是脑神经影像学研究(如功能磁共振成像)在创伤后应激障碍中的应用日益增多。脑功能磁共振成像技术不仅能够直观的观测到患者具体病变的脑区部位而且能够观测到其脑区神经回路的转变，对神经精神疾病的发病机制的研究具有重要作用。本文主要综述脑功能磁共振成像技术在创伤后应激障碍中的应用及进展，并提出今后可能的研究方向。 Post-traumatic stress disorder (PTSD) is stress related disorders by individual direct or indirect contact with natural disasters, wars, sexual abuse, serious traffic accidents, long-term imprison-ment and torture after a traumatic event, a disease causing serious damage to the individual's physical and mental health and social adaptability. In recent years, with the rapid development of medical imaging technology, research on the pathogenesis of post-traumatic stress disorder, more deeply, more from the perspective of imaging neuroscience to explore the mechanism of its occurrence and development, especially the study on brain imaging (such as functional magnetic resonance imaging) application in post-traumatic stress disorder is increasing. Functional magnetic resonance imaging technique can not only intuitively observe the brain areas in patients with specific lesions but also observe the changes of neural circuits in the brain area; it is very important to study the pathogenesis of neuropsychiatric disorders. This paper reviews the application and progress of brain functional magnetic resonance imaging in post-traumatic stress disorder, and puts forward the possible research directions in the future.