Abstract
A case of pemphigus vulgaris presenting initially with symptoms of an incurable ulcer of the oral cavity is reported. A 57-year-old female visited our hospital owing to pain and bleeding of her oral cavity. She had consulted several departments of dermatology and internal medicine in the previous 6 months, but symptoms did not improve. Vesicles appeared on the skin and half months after the initial symptoms of stomatitis. The diagnosis of pemphigus vulgaris was supported by biopsy and histopathologic examination, which revealed spurabasal splitting of the epithelium and progressive loss of intercellular attachments. Immunofluorescence study detected IgG along the intercellular margins. Predonisolone was administered to this patient, and the stomatitis and skin vesicles improved after treatment.
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