注射薬混合時に用いる各種シリンジフィルターへの薬物吸着に関する検討

Abstract

We evaluated drug adsorption onto syringe filters used in the preparation of injectable mixtures in the clinical setting.Bovine serum albumin (BSA) and fifteen injection preparations for total parenteral nutrition (TPN),chemotherapy,and therapeutic drug monitoring (TDM) were evaluated for adsorption in the case of using three syringe filters which were made of polyethersulphone (PES),hydrophilic polyvinylidene fluoride (PVDF),and mixed esters of cellulose nitratecellulose acetate (MEC) membranes,i.e.,PALL® PharmAssure® HP 1002,Millex® GV and Millex® GS,respectively.A significant decrease in the passage rate of BSA was observed with the PVDF and MEC filters at the first filtration and BSA was adsorbed onto the MEC filter to a greater extent than the other two filters.With the exception of digoxin and GCSF,the injections examined were not significantly adsorbed onto the syringe filters.The adsorption of digoxin onto the MEC membrane was particularly significant and G-CSF was significantly adsorbed onto all the filters,in particular the MEC filter (adsorption greater than 80%).These results indicated that most of the injections examined can be used safely in the clinical setting with no appreciable drug loss due to adsorption onto filters used in their preparation.However,as digoxin and G-CSF were adsorbed onto the syringe filter to an appreciable extent,particularly onto the MEC filter,caution must be exercised because a decrease in drug content may jeopardize clinical efficacy.In conclusion,it is necessary to pay attention to the variation in adsorption properties among injections with respect to syringe filters,as well that among filter membranes made of PES,PVDF,and MEC,to ensure that injection mixtures are prepared appropriately.