キラルスルホキシドを用いる有機合成

Abstract

The progress in the asymmetric synthesis using chiral sulfoxides is reviewed based on the literature results since 1983. The asymmetric synthetic methods are classified into the type of the reactions ; reaction of α-sulfinylcarbanions, reduction of β-ketosulfoxides, 1, 4-addition reaction to α, β-unsaturated sulfoxides, asymmetric synthesis using Pummerer-type reactions, and asymmetric cycloadditions. Mechanistic aspects of asymmetric Diels-Alder reaction using chiral α, β-unsaturated sulfoxides and its application to organic synthesis are discussed on the basis of the results obtained quite recently in the author's laboratory.