新型眼部给药系统及其体内外评价方法的研究进展

Abstract

目的：介绍眼部给药系统及其体内评价方法的进展。结果：通过查阅总结近年来眼部给药系统及其体内评价方法的国内外文献报道，总结发现近年来新型眼部给药系统有凝胶系统、胶粒系统、环糊精包合物等，其体外评价方法主要为体外释放实验，其体内评价方法主要包括眼部滞留时间和药动学研究。结论：新型眼部给药系统及其体内外评价方法都有较大的进展，虽然还存在一定的不足，但均具有很好的发展前景。 Purpose: The purpose is to introduce the progress of ocular drug delivery system and its in vivo and in vitro evaluation methods. Results: Through looking up and summarizing the domestic and foreign literature about ocular drug delivery system in recent years, we find that new ocular drug delivery system is usually about gel system, colloidal particle system, entrapped cyclodextrin complex, etc. Its in vitro evaluation method is mainly in vitro drug release experiment, and the in vivo evaluation methods mainly include ocular residence time and pharmacokinetic study. Conclusion: New type of ocular drug delivery system and its in vivo and in vitro evaluation method are improved. Though there is a certain amount of shortage, they have a very good development prospect.