Abstract
In the preceding paper we reported that glycyrrhetinic acid, a hydrolytic product of glycyrrhizin which is a component of Kanzoo, oriental drug plant, showed an inhibiting action for trypsin. This time, we synthesized several glycyrrhetinic acid derivatives by the known method and anti-tryptic activity of them was tested. Among these derivatives, glycyrrhetinic acid nicotinate morpholine salt, glycyrrhetinic acid piperonate, glycyrrhetinic acid cinnamate morpholine salt, glycyrrhetinic acid p-methoxycinnamate, and glycyrrhetinic acid nicotinate showed the strong inhibiting activity compared with the parent compound.
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Schedule a callMore From: Journal of the agricultural chemical society of Japan
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