ポーラログラフ法による末梢循環に関する研究

Abstract

The polarographic method for the measurement of the oxygen tension in tissue is a beneficial addition to the group of the methods available for the study of the peripheral circulation.In this paper, the author analysed 1) the blood flow change in the muscle and the skin, 2) role of the arteriovenous anstomosis (AVA), in combination with the skin temperature measurement by thermocouple, the finger volume plethysmograph and N24 clearance.The summary and conclusion of the experiment were as follows.1) The apparatus used is simular to what was described by Davies and Brink. The reliability, and the influence of the physico-chemical factors were retested, and it was concluded that this method could be available for the study of the peripheral circulation.2) By arterial occlusion, the skin PG and muscle PG descended and by oxygen inhalation they ascended. In this respect some consideration was made about the oxygen consumption of tissue, the oxygen diffusion and the blood circulation time.3) It was found that the skin PG showed the spontaneous fluctuation and moreover, every simultaneous record at two points of the body showed high correlation. It seemed the fluctuation might be in close relationship with the blood flow change caused by the nervous control probably in the vicinity of the arterioles.4) When the skin PG and temperature were recorded simultaneously, both curves often showed close simularity. It was suggested that the skin temperature change might in some occasion indicate the skin capillary blood flow change. Contrally, in the cases of poor correlation between them the explanation may be possible by increased blood flow through the AVA, where it is supposed that the oxygen can scarecely pass through the wall and that fluctuation differs from that of the arteriole.5) Simultaneous record of the skin PG and finger volume plethysmograph were carried out and in some occasion they showed correlation. This is a interesting finding to evaluate each method.6) The reactive hyperemia after release of arterial occlusion and caloric vestibular stimulation were studied and no definite tendency was seen polarographically.7) The spontaneous fluctuation was seen in the muscle PG which as in the case of the skin PG showed close simularity when recorded at every two points. And, the muscle PG had no close correlation to the skin PG.8) The reaction to cold, "Hunting" phomenon by Lewis, was studied with simultaneous record of skin PG and skin temperature during finger cooling. Both curves showed the huntung in much simular way. And, at various points of the hunting shown by temperature curve, oxygen inhalation lets the PG elevate variously. The interpretation is that the hunting depends not mainly upon the increase of blood flow of AVA, but upon the change of capillary blood flow.9) The changes of the muscle PG and the skin PG in indirect thermal application were compared with the reports based upon the conventional methods. By polargraphic method it may be possible to analyse the blood flow changes in the skin and the muscle separately.Also, the blood flow change of muscle and skin in Adrenaline administration were studied.