Abstract
We have been performing endoscopic suergery, in which the Nd-YAG laser is irradiated under bronchofiber scopic observation, or the therapy by argon dye laser photoirradiation combined with the administration of hematoporphyrin derivative (HpD) on patients with lung cancer since 1980. After the laser photoirradiation, the exposed lung cancer cells show degeneration, necrosis and fibrosis. These changes were histopathologically compared using biopsy specimens obtained under bronchoscopic observation and opration specimens. The tissue specimens were examined primarily concerning chages in the bronchial wall according to the criteria for the evaluation of effects of the conservative treatment suggested by Oboshiand Shimosato (Grades 0 to IV).The determination of the histopathological changes occurring in lung cancer following laser photoirradiation proved helpful to the improvement of the irradiation conditions and methods.
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