Abstract
It has been well established that adenosine phosphate added into the storage fluid may prolong the storage period of the blood. However, this agent may exert some toxic effects, which requires careful study. In order to elucidate these effects and to maintain safety in practical use of this agent, we have observed, using white mice as the experimental animals, its deleterious effects on the internal organs and their functions. The results of the experiments indicated that this agent caused damage not only on the kidneys but also on various other internal organs such as liver, spleen and thymus etc. The liver and kidneys were more seriously injured. When it was used in the dosage of 10mg/kg, it revealed relatively mild histopathological changes in the internal organs in a part of the experimental animals. However, when the dosage was increased to 200-300mg/kg the experimental animals showed reduction in body weight, changes in the weight of different organs with serious histopathological changes, particularly when 300mg/kg was used. Simultaneously we observed the alteration of functions of these affected organs and the blood as well. Evidently the toxicity of APO4 is systemic and related to the dosage of the preparation used.
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