Abstract
Twelve female donors received four plasmapheresis at 7 day-interval. Apheresis was done using Haemonetics V50 machine. Blood samples were obtained just before each run, immediately after the last apheresis and then 1, 2 and 4 weeks after the 4th apheresis.Complete blood cell counts revealed significant decrease in RBC and hematocrit values. White blood cells and platelets were unchanged. Fibrinogen increased significantly two weeks after the 4th apheresis, however, decrease in antithrombin III was observed even after the 2nd plasmapheresis. Second procedure resulted decrease in total serum protein, IgG, IgA and IgM concentrations, which remained lower for several weeks. Serum albumin and total cholesterol levels were unchanged.Most donors represented moderate fall in blood pressure, and a few complained chills and/or mild paresthesias (citrate toxicity) during apheresis. After apheresis, eighteen procedures (in nine donors) of 48 plasmapheresis resulted general fatigue, and these symptoms continued for two to 24 hours. These symptoms were similar to those of generalized disequilibrium syndrome found in patients undergoing hemodialysis. Further study on serum oncotic pressure is needed and removal of less plasma volume should be considered.
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