Abstract
Photo degradable drug powder was stabilized by dry coating drug agglomerates with UV protective powder with a high-shear mixer. As an example, pyridoxal phosphate (PLP) was used as the drug powder and titanium dioxide (TiO2) as a protective one. The drug forms a subcomponent under UV irradiation and the amount of the components was measured by high performance liquid chromatography. As a result, the UV protective performance improved with the mass ratio of TiO2 to PLP, the number of coating operations and the PLP agglomerate size.
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