Abstract
We have fabricated a minimally-invasive “bubble injector” on a chip which penetrate and transport with microbubbles. To achieve high-throughput injection, multiple bubble injectors on a chip is proposed. In this time, we have successfully fabricated flow channel supplying medicines to the tip of an injector. This channel is sealed with the thin PDMS membrane for in-vivo use. The ambient flow around high-speed ejected bubbles can produce the negative pressure in the closed-space between the membrane and electrode, while the line of high-speed micro-bubbles tries to thrust the membrane to break-down. This study has potential to contribute to be used as on-demand injecting system for biomedical field.
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