骨髓穿剌に関する基礎的研究

Abstract

I have taken some investigations on the manipulation of intramedullary transfusion, along with on the effects of the transfused blood on bone-marrow vessels, parenchyma, as well as the peripheral blood picture; then, further about the fate of blood used for the blood transfusion.(1) It has been observed that sinus nets have increased its capacity to an maximum extent, immediately after the blood transfusion, centering on a part of blood transfusion, so that the diameter of sinuses has become several times larger that of normal one; though it is evident that certain sinus nets would never succumbed to change. The destruction-ends of sinuses owing to marrow-puncture have already been blockaded immediately after the operation. Some sort of recovery on the part of vessels was taken place in an area destructed in the bone marrow, due to blood transfusion; which probably would cost it 7 days or so until the entire regeneration has been achieved. No intersinusoidal capillaries could be detected in those sinus nets.(2) Though such sinuses as the collective sinuses which were not affected by the marrow puncture, or the principal sinus that were not subjected to ordinary obstruction, have increased their volume after the transfusion on a sudden, no self-destruction occurred; which, it would cost 2 or 3 days to recover normality; in some cases, even after 5 days, entire recovery could not occur.(3) Arterial capillaries have been influenced in no wise at the time of puncture, except they suffered the destruction; even in that circumstance, their destraction-hole would be closed in two days lapse.Moreover, no marked change occurred to the position of arterial capillaries and capacity, under the blood transfusion.(4) Almost no vessel destruction would happen to both the paralell arterial branches or the principal artery, due to the marrow puncture, and transfused blood; besides, neither the positions nor the capacity proved change at all.(5) A marked appearance of nucleated erythocytes were detected in peripheral blood after the blood transfusion, but it would decrease in paralell whith the regeneration of sinus nets. so, after 5-6 days, no trace has been detected.(6) The left shift of nuclear is wont to cotinue till 7th day from the operation, at leucocyte picture, arriving at the climax 2 or 3 days after. Also, the leucocytes stood in a correlation with those pseudoeosinophilic lucocytes which, even if would decrease for a while after the blood transfusion, increases on the spot, regenerating gradually into the normal state in 24 hours.(7) As to the fate of transfused blood, a part would invade directly into sinuses at its end, then went out of the body; while other part, though existing for a while between the sinus-wall and the parenchyma, in gradual stage demolish sinuswall, shifting into the sinuses and out of the bone-marrow. Further, that part of transfused blood destructed in parenchyma has turned to Hemosiderin, and been absorbed as foreign matter.