実験的家兎絹雲母肺症と肺結核との相関関係に関する研究

Abstract

For examining the interplay between pulmonary sericitosis and pulmonary tuberculosis in complication with it, rabbits with experimental sericitosis induced by inhalation of sericite dust were inoculated with bovine type tubercle bacilli. The experiment was also performed in the reverse order. Simple tuberculous and simple sericitotic rabbits were used as controls. The following conclusions were arrived at in summary: 1. Of the animals with induced simple sericitosis, the milder cases showed only right pulmonary change consisting in scattered or aggregated dusty cells in the alveoli; while the severer cases showed graver changes of glanulomata formed on the alveolar walls, the peri-bronchial lymphfollicles, the lymphnodules in the pulmonary hilus and so on, but no suspicion of fibrosis as in silicosis was observable. The correlation, however, between the duration of the dust inhalation and the grade of pathological changes was not always clear. 2. Since low-virulence vovine type tubercle bacilli were used for inducing tuberculosis, the changes in the lungs of the rabbits with simple pulmonary tuberculosis were of the exsudative in only very few of the cases, and the disease showed a marked tendency for recovery. 3. In the animals infected both with sericosis whether the tuberculous was induced before or the sericitosis, the tendency to exsudation and necrobiosis being notable in the former, but no finding suggestive of the sericitotic changes accelerating the infection of tuberculois was observable. 4. From the above results, it can be understood that inhalation of the endothelial cells in the pulmonary tissues and weaken their inhibitory function against the progress of tuberculosis.