塩酸リトドリンの輸液中での安定性

Abstract

The stability of ritodrine hydrochloride (RTD) in infusion solution was studied by using highperformance liquid chromatography (HPLC) in consideration of the practical condition in hospitals. RTD was stable in the case of the single addition into infusion solution (5% glucose solution). However, the decomposition of RTD in infusion solution was promoted by the concomitant addition of the following injections: 20mg riboflavin sodium phosphate (B2), 20mg flavin adenine dinucleotide (FAD), 1M potassium chloride containing 3mg B2 (KCl), Adelavin No.9. When the solution was exposed to scatterd light (2000 lux, 6hrs), the residual rate of RTD was 37.5%, 69.4%, 60.1% and 81.4% in the presence of B2, FAD, KCl and Adelavin No.9 respectively, compared with 100.4% in the case of no addition. The decomposition of RTD, perhaps due to photooxidation sensitized by B2, was obviously suppressed by shading the light or adding the antioxidant such as vitamin C.As a main decomposed product of RTD, p-hydroxybenzaldehyde (PHA) was identified by HPLC.