Abstract
There are some reports on immunological investigation for the role of human sex ratio. We investigated the rate of sex in the patients with ossification of the posterior longitudinal ligament (OPLL).The male-female sex ratio among the patients and their brothers and sisters were evaluated.Among the first-born ones the tatio of male-female was 1.95/1.00 (with p<0.01). Considering all of them together the ratio of male-female was 1.44/1.00 (with p<0.01).Some special HLA-haplotypes were recognized in the patients with OPLL. From these results, We concluded that some immunological roles influence on the excess male births among the patients with OPLL.
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