Abstract
A 65-year-old woman inpatient had been administered methyldigoxin, verapamil and warfarin for the treatment of artrial fibrillation and mitral stenosis disease. About six day after the start of treatment the dose of methyldigoxin was increased from 0.1 to 0.2 mg/day and, as a result, a visual disturbance occurred. However, no other side effects of digoxin were not presented and the serum digoxin concentration was found to be within the normal therapeutic range. The dose was decreased and about five days later, her side effects disappeared. This case suggested that such side effects of digoxin as visual disturbance therefore need to be carfully monitored when ever digoxin and verapamil, which is one of the inhibitors of P-glycoprotein, are coadministered.
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