狂犬病ワクチンおよび免疫血清併用の予防効果に関する実験的研究

Abstract

Although the use of antiserum, combined with a course of vaccine, has been recommended recently in the prophylaxis of rabies, the experimental basis of this procedure is not yet obtained.In studies reported here, effects of passively injected antiserum on the immunizing activity of UV vaccine were examined in experimental rabies in mice.Ultraviolet inactivated vaccine and rabbit antiserum were injected into mice with various intervals, then antibody levels in the blood and the resistance to intracerebral challenge of fixed virus were followed up to 4 weeks.The resistance of mice injected with vaccine and antiserum simultaneously, were much lower than those of control mice injected vaccine alone. The production of antibody was also completely depressed.Even when antiserum were introduced 5 days before vaccination, the development of both resistance and blood antibody were completedly depressed.Antiserum injected 3 and 7 days after vaccination, could not alter the development of immunity by vaccination.From these results, some considerations on the problems of human antirabies treatment were discussed.