Abstract
In this article, the concept and clinical impact of the staging systems for hepatocellular carcinoma (HCC) were reviewed. Among the several scoring systems so far available, such as Barcelona Clinic Liver Cancer (BCLC), Cancer of the Liver Italian Program (CLIP), and Japan Integrated Staging (JIS) systems, the JIS system is extremely efficient in the stratification ability of the HCC patients from the very early stage through highly advanced stage of HCC: particularly in the areas like Japan, where small HCC less than 2 cm in diameter can be diagnosed based on the screening program for early detection of HCC. This efficiency of the JIS system is due to an excellent tumor-node-metastasis (TNM) staging system developed by Liver Cancer Study Group of Japan (LCSGJ). JIS system is an integated staging system between child-Pugh stage and the TNM stage by LCSGJ. Therefore, the TNM stage by LCSGJ and the JIS score is expected to be used as a global standard staging system in the near future.
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