Abstract
Renal scars have been considered to occur in later stages of chronic pyelonephritis. In our experimental pyelonephritis models bacteria which possessed mannose-sensitive (MS) pili promoted renal scarring following inoculation to the renal parenchyma. Polyethylene glycol modified superoxide dismutase (PEGSOD), 2-0-octadecyl ascorbic acid (CV3611), dapsone and steroid significantly suppressed scarring when parenterally administered during the early stage on kidney infection. These had no effect on bacterial growth in the kidney.These findings suggest that the superoxide and other active oxygens play an important role in renal scarring following infection and that PEG-SOD, CV 3611, dapsone and steroid may be agents capable of preventing renal scarring.
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