癌のリンパ節転移に及ぼすレ線前照射の影響に関する実験的研究

Abstract

On nidation of cancer cells a pure physical study of their permeability. was performed Further the irradiated lymphnodes were studied histologically and morphologically from a pure physical standpoint especially on their lymph stream way. The results were as follows:1) After prophylactic radiations of 60 r, 600 r or 300 r×5, the little granuli (the spores of myxomycetes), the size of small cancer cells, were injected into the lymphnodes. Then their permeability was compared with that of the non-irradiated lymphondes. The spores generally decreased with the lapse of time in the latter while in the former the permeability was disturbed and the spores remained for comparatively long time.2) Instead of the spores, Brown-Pearce tumor cells were injected. The result was the same as in the case of the spores. They remained for longer period in the marginal sinus and in the intermediate sinus of the lymphnodes which had been irradiated with 600 r and 300γ×5.3) The lymph sinus as a way of lymphatic stream was dilated in case of irradiation by 600 r and 300 r×5 both in marginal and marrow sinus. Also a lymphatic stagnation was found.4) It seems that the delay and slowness of lymph stream which comes from the dilation of lymph sinus is the reason of the spores or the Brown-Pearce tumor cells remaining comparatively in number when 600 r and 300 r×5 X-rays are radiated to the lymphnodes.5) The reticular fibres which lay relatively densely at the border of the intermediated and marrow sinus are considered to hold the stream of the little granuli or tumor cells from the marginal sinus into the marrow sinus to some degree.6) The prophylactic radiation is considered to make the nidation of cancer cells easier.