Abstract
In the present experiment, we studied the effects of Cytimun on collagen arthritis in Sprague-Dawley rats and compared its effects with those of Cyclophosphamide. A 15-day course of Cytimun administration at a dose of 10mg/kg per day, begun on the day before type II collagen immunization, suppressed the development of arthritis as well as humoral response to type II collagen but not delayed-type hypersensitivity (DTH) skin reaction. When Cytimun was administered at a dose of 20mg/kg per day, not only humoral response to type II collagen but also DTH skin test response were suppressed.Administration of Cyclophosphamide showed similar effects but required less doses than those of Cytimun.The mechanism by which Cytimun exerts its effects on the immune system is not clearly understood, but the results of the present study support the observations of Brock et al. that the suppressive effect of Cytimun on antibody formation may be a result of its selective suppression of B lymphocytes. The results of this study further support the concept that humoral immune response to type II collagen might be more intimately associated with the development of collagen arthritis.
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