実験的僧帽弁閉鎖不全犬におけるニトログリセリン軟膏の口腔粘膜塗布効果

Abstract

The hemodynamic effect of nitroglycerin ointment (NGO) administered on oral mucosa was investigated at 30 min intervals in five normal and five experimental mitral regurgitation (MR) dogs. After administration of 15 or 100 mg, the mean arterial pressure (MAP) decreased in all cases. MAP were observed attaining the lowest at 90 and 30 min in the normal and MR groups respectively and subsequently returning to the level before administration except for the MR-15 mg cases. Showing a significant increase even after 150 min. The mean pulmonary arterial pressure (MPAP) decreased and subsequently returned to the level before administration except for the MR-15 mg cases. Showing significant increase after 300 min. In the normal-15 mg cases, there were significant increase in cardiac index at 270 min and in heart rate at 30 min but not in other cases. The double product (systolic arterial pressure × heart rate) decreased in all cases, later significantly increased at 240 min in the MR-15 cases.