有機ビスマス化合物を用いた有機合成の最近の進展

Abstract

Organic synthesis using organobismuth compounds has considerably advanced during the last 15 years. One of the bottlenecks using organobismuth compounds in organic synthesis was their limited accessibility because of lack of variety of synthetic methods. Several new synthetic methods for organobismuth compounds have recently been developed, which allowed the access to wider variety of organobismuth compounds useful in organic synthesis. Considerable advancement has been achieved in cross-coupling reactions forming C-C, C-O, C-N, C-S and C-Se bonds using organobismuth reagents. Not only the arylation reaction, but also alkenylation and alkylation reactions became possible. Stereoselective allylation reaction of carbonyl compounds as well as 1,4-addition reaction of α,β-unsaturated carbonyl compounds have also been developed. There was also noticeable advancement in oxidation reaction, in which highly reactive and selective oxidation reagents have been developed. Catalysis by organobismuth compounds including CO2 fixation reaction, cross-condensation reaction, radical and cationic polymerization reaction has also been achieved.