パンテチンの抗動脈硬化作用について

Abstract

Rats were fed in the following manner, 1) Normal diet for 16 weeks 2) High cholesterol diet for 8 weeks and then normal diet for 8 weeks 3) High cholesterol diet for 8 weeks and then normal diet plus pantethine for 8 weeks 4) High cholesterol diet for 16 weeks 5) High cholesterol duet for 8 weeks and then high cholesterol plus pantethine for 8 weeks 6) High cholesterol diet plus pantethine for 16 weeks. Serum cholesterol level in rats fed a high cholesterol diet for 16 weeks was considerably higher than in rats fed a normal diet for 16 weeks. The increased serum cholesterol was significantly lowered by administration of pantethine for 16 weeks or last 8 weeks. Acid cholesterol activity in rat arterial wall extract fed a high cholesterol diet was less than that in normal diet for 16 weeks. The activity in groups administered pantethine was increased more than that of controls. The ratio of cholesterol ester synthesizing activity to alkaline cholesterol esterase activity was increased in arterial wall extract from rats fed a high cholesterol diet for 16 weeks than in those from rats fed a normal diet for 16 weeks.The ratio in arterial wall extract from rats fed a high cholesterol diet administered pantethine for 16 weeks was lower than in those from rats fed a high cholesterol diet for 16 weeks. These results suggest that the deposition of cholesterol ester might be increased in lysosome or microsome of arterial wall and pantethine might protect the deposition.