Abstract
We investigated the effect of irradiation and leukocyte filtration on red cells in MAP solution (RC-MAP) for premature infants.RC-MAPs were stored for 3 or 7 days and pretreated with 15-Gy irradiation and a leukocyte depletion filter, with either the irradiation or filtration performed first. Infusion was performed using an infusion pump for 8hr at a speed of 2ml/hr through a 4-ml, 100-cm tube and a 24G needle passing into an infant incubator warmed to 34°C.Free hemoglobin concentration in the supernatant of tested RC-MAP stored 7 days and irradiated after filtration was increased to the maximum level of 42.6mg/dl.Potassium ion level in the supernatants and ATP and 2, 3-DPG concentration in red cells from tested RC-MAP were similar to pretreated values. Maximum potassium ion level was increased to 23.5mEq/l.Our results showed that both irradiation and filtration against RC-MAP solutions stored for 3 or 7 days is safe for use with premature infants in warmed incubators. However, further investigation is necessary to clarify the risk of bacterial contamination in such transfusion situations.
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