Abstract
Mammary carcinoma with multinucleated osteoclast-like giant cells (OCGCs), an uncommon neoplasm, features giant cells morphologically resembling osteoclasts. A 76-year-old woman noticing a left breast cystic mass was found in fine-needle aspiration cytology (FNAC) to have many atypical epithelial cells with OCGCs. Immunohistochemical studies indicated that OCGCs were of histiocytic origin. FNAC specimens make it easy to observe OCGCs, so FNAC becomes useful in diagnosing breast carcinomas with OCGCs.
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